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Analysis of ACE2 gene encoding protein in mammalian species
Ying,Cao1,2,3; Yeping, Sun1; Xiaodong, Tian1; Zhihua, Bai1,4; Gong Yue5; Jianxun, Qi1; Di, Liu2,4; Wenjun, Liu1,4,6; Jing, Li1,4
2020-07-03
Source PublicationFrontiers in Veterinary Science
Issue7Pages:457
Abstract

Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being the elderly or people with potential chronic diseases or in immunosuppressive states. According to big data analysis, there are many proteins homologous to or interacting with the angiotensin-converting enzyme 2 (ACE2), which, therefore, may not be the only receptor for the novel coronavirus; other receptors may also exist in host cells of different species. These potential receptors may also play an important role in the infection process of the novel coronavirus. The current study aimed to discover such key proteins or receptors and analyze the susceptibility of different animals to the novel coronavirus, in order to reveal the transmission process of the virus in cross-species infection. We analyzed the proteins coded by the ACE2 gene in different mammalian species and predicted their correlation and homology with the human ACE2 receptor. The major finding of our predictive analysis suggested ACE2 gene-encoded proteins to be highly homologous across mammals. Based on their high homology, their possibility of binding the spike-protein of SARS-CoV-2 is quite high and species such as Felis catus, Bos taurus, Rattus norvegicus etc. may be potential susceptible hosts; special monitoring is particularly required for livestock that are in close contact with humans. Our results might provide ideas for the prevention and control of the novel coronavirus pneumonia.

KeywordCovid-19 Sars-cov-2 Ace2 Gene Protein Mammals
MOST Discipline Catalogue理学::生物学
DOI10.3389/fvets.2020.00457
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.las.ac.cn/handle/12502/11114
Collection中国科学院文献情报中心(北京)_学科咨询服务部
Affiliation1.CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
2.CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
3.College of Animal Sciences and Veterinary Medicine, Guangxi University, Nanning, China
4.Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
5.National Science Library, Chinese Academy of Sciences, Beijing, China
6.Center for Biosafety Mega-Science, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
First Author Affilication中国科学院文献情报中心
Recommended Citation
GB/T 7714
Ying,Cao,Yeping, Sun,Xiaodong, Tian,et al. Analysis of ACE2 gene encoding protein in mammalian species[J]. Frontiers in Veterinary Science,2020(7):457.
APA Ying,Cao.,Yeping, Sun.,Xiaodong, Tian.,Zhihua, Bai.,Gong Yue.,...&Jing, Li.(2020).Analysis of ACE2 gene encoding protein in mammalian species.Frontiers in Veterinary Science(7),457.
MLA Ying,Cao,et al."Analysis of ACE2 gene encoding protein in mammalian species".Frontiers in Veterinary Science .7(2020):457.
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